Antibiotics penetrate cns
Direct injection of drugs, which do not readily penetrate into the CNS, into the ventricular .. CSF penetration and clinical use of different classes of antibioticsa .
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CSF penetration and clinical use of different classes of antibiotics for CSF penetration), AUCCSF/AUCS, Relationship of CSF concn to MIC with usual doses.
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Description:In order to ensure the proper function of the CNS, a variety of small molecules able to penetrate lipid membranes to a certain extent, e. The intracranial-intraspinal space consists of several compartments. This is particularly true for infections caused by penicillin-resistant pneumococci, methicillin-resistant staphylococci, multiresistant Gram-negative aerobic bacilli, or several other organisms including Aspergillus spp. When several equally active compounds are available, a drug which comes close to these physicochemical and pharmacokinetic properties should be preferred. Conversely, after the direct injection of trypan blue into the CSF, the brain and spinal cord were stained, indicating the absence of a tight diffusional barrier between CSF and brain tissue 80 ,